HA + Peptide Repair Serum bottle
Winona is rated 4.6
  • Core

HA + Peptide Repair Serum

with Ceramides + Resveratrol

This peptide serum was built for skin from perimenopause to postmenopause that looks dry, dull, or depleted. It pairs a dual-peptide complex with multi-layer hydration and barrier-supporting lipids to help skin look visibly firmer, smoother, and more hydrated.

  • Helps skin look visibly firmer and more refreshed
  • Softens the appearance of fine lines and expression lines
  • Supports a hydrated, plumper-looking complexion
  • Designed for skin in perimenopause through postmenopause
  • Clinically-proven ingredients
  • Physician-curated skincare system
Why you need it

Declining estrogen sets off a chain of visible changes to skin, including skin looking less firm, fine lines deepening, and texture flattening. Skin that once held moisture easily starts to feel persistently dry and depleted. The serums that may have worked before often can't keep up with these changes. HA + Peptide Repair Serum was formulated specifically for skin in the menopause transition and beyond; it pairs a dual-peptide complex with multi-layer hydration and barrier-supporting lipids to help skin look visibly firmer, smoother, and more hydrated.

How it works

A dual-peptide complex supports the look of smoother, firmer skin and softens the appearance of fine lines and expression lines. Sodium hyaluronate and sodium PCA draw and hold hydration for a plumper, more refreshed look. Ceramide EOP, squalane, and phospholipids provide barrier-supporting lipids that help skin feel comfortable and moisturized. Resveratrol and green tea extract provide antioxidant support against the visible effects of environmental stressors. Together, the formula works at multiple levels to support changing skin in the menopause transition.

How to use it

Apply HA + Peptide Repair Serum after cleansing and before your moisturizer and SPF. Use 3–4 drops, massaging into the face, neck, and décolletage with gentle upward motions, then let the serum absorb fully before your next step. Use morning and night for the best firming and hydrating results.

Ingredients
  • Dual Peptide Complex (Palmitoyl Tetrapeptide-7 & Palmitoyl Hexapeptide-19): Clinically-proven peptides that help support smoother-looking skin and soften the appearance of expression lines that deepen as estrogen declines
  • Sodium Hyaluronate & Sodium PCA (HA Complex): Humectants that draw hydration into skin, addressing the dryness that becomes more common during the menopause transition
  • Barrier Lipid Complex (Ceramide EOP, Squalane & Phospholipids): Barrier-supporting lipids that help skin feel comfortable and moisturized
  • Antioxidant Complex (Resveratrol, Green Tea Extract, Tocopherol & Haematococcus Pluvialis Extract): Antioxidants that help defend against the visible effects of environmental stressors
  • Mineral Ferment Complex (Magnesium, Iron, Copper, Silicon, Zinc): Five bio-available mineral ferments that help nourish and condition the skin
  • Apple Stem Cell Extract (Malus Domestica Fruit Cell Culture Extract): Botanical extract to help nourish and condition the skin, supporting a more refreshed appearance
  • Botanical Oils (Sunflower, Apricot Kernel, Avocado): Help soften and nourish dry-feeling skin that becomes more common during the menopause transition
  • Glycerin: Foundational humectant that helps skin retain moisture

Frequently bought together

Exactly what HA + Peptide Repair Serum does for your skin

Visible support for the firmness, hydration, and texture changes that appear during the menopause transition

Immediate results:

  • Skin looks more hydrated and refreshed
  • Skin texture appears smoother and more even
  • Makeup applies more evenly, without settling into lines

Long-term results:

  • Appearance of fine lines and expression lines softens
  • Skin appears visibly firmer, smoother, and more plump
  • Previously dull, dry-looking skin becomes more supple and luminous
Face after 2 months of use with HA + Peptide Repair Serum
Face before use of HA + Peptide Repair Serum
Beforeproduct usage
After 2 months of usewith HA + Peptide Repair Serum

This image is AI-generated and is intended solely to demonstrate product usage.

The formula for hydrated, firmer-looking skin in menopause

Results you’ll love, backed by science

  • Peptide Complex(Palmitoyl Tetrapeptide-7 & Palmitoyl Hexapeptide-19)

    Peptide Complex
    What it is A peptide duo composed of short amino acid chains that interact with the skin's surface
    Why we use it Helps support smoother-looking skin and softens the appearance of fine lines and expression lines

  • Barrier Lipid Complex(Ceramide EOP, Squalane & Phospholipids)

    Barrier Lipid Complex
    What it is A barrier-building lipid complex of essential fats
    Why we use it Supports the skin barrier to feel more comfortable and moisturized

  • Resveratrol

    Resveratrol
    What it is Powerful, plant-derived, age-defying antioxidant
    Why we use it Stimulates collagen production, neutralizes free radicals, smooths and firms skin & defends against environmental toxins

Your complete system for great skin in every decade

These three key functions create healthy, beautiful, and resilient skin that maintains its look through the menopause transition and beyond.

Skincare with purpose

  • Core

    Cleanse, hydrate & preserve skin barrier function.

  • Defense

    Protect against environmental stressors & toxins.

  • Renewal

    Target visible signs of aging & skin damage.

Build out your routine.

HA + Peptide Repair Serum is part of the Core line and pairs well with:

Woman holding a bottle of HA + Peptide Repair Serum next to her face
Core

HA + Peptide Repair Serum

Skincare of a higher standard

Formulated with clinical precision and the ingredients your skin actually needs

Others

Designed for skin in perimenopause to postmenopause

Physician-curated formula

Clinically-proven peptide duo (Palmitoyl Tetrapeptide-7 + Palmitoyl Hexapeptide-19)

Multi-layer hydration and barrier-supporting lipid complex

Antioxidant complex for visible environmental defense

A routine you’ll understand, for results you’ll see & feel

Skincare FAQs

What is the best firming serum for menopause skin?

The best firming serum for menopause skin uses peptides and other ingredients for barrier support and multi-layer hydration. HA + Peptide Repair Serum supports firmer-looking skin, softens the appearance of fine lines, and delivers lasting hydration to dry, depleted-looking skin with its physician-curated formula specifically made for skin in this stage of life.

Is peptide serum good for menopause skin?

Yes. A peptide serum is especially well-suited to menopause skin that looks less firm, dry, dull, or depleted. The peptide duo in HA + Peptide Repair Serum helps support smoother-looking skin and soften the appearance of fine lines, addressing the visible changes that deepen with estrogen decline.

Can I use a firming serum during perimenopause?

Yes. HA + Peptide Repair Serum is designed for the visible skin changes that appear during perimenopause and continue through menopause and postmenopause, including dryness, fine lines, uneven texture, and skin laxity. The formula works from perimenopause forward, so starting during the transition supports visible results you can sustain.

Does this serum help with the look of less firm skin?

Yes. With consistent use, skin looks smoother, more hydrated, and visibly firmer. The peptide duo targets the appearance of less firm skin that comes with estrogen decline, while sodium hyaluronate and sodium PCA plump skin with lasting hydration.

Is this serum good for dry menopause skin?

Yes. The formula was built around multiple layers of hydration and barrier support; sodium hyaluronate, sodium PCA, ceramide EOP, squalane, phospholipids, and botanical oils all work together to support hydration and help skin feel more comfortable. For skin that feels persistently dry during the menopause transition, this combination addresses dryness at the surface and at the barrier level.

Who should use caution before applying?

This is a rich formula. If you have active acne breakouts or very oily skin, the oil and lipid content may feel too heavy for you. If you have known sensitivities to yeast-derived ferments, botanical oils, or limonene and fragrance components, patch test before full-face use. And if your skin barrier is currently compromised or irritated, let it settle, or check with a dermatologist, before introducing new active products.

What combination of skincare products do I need?

Our Core → Defense → Renewal system makes it simple. Cleanse and moisturize daily (Core). Protect with antioxidants and SPF (Defense). Add targeted treatments for the specific signs you most want to address (Renewal).

What makes Winona's skincare different from other products?

Winona's skincare is physician-curated and designed specifically for women in the menopause transition and beyond. Our line uses clinically-proven ingredients chosen for the visible changes that appear at this stage of life. While it was created with menopausal women in mind, the line serves as premier skincare for any woman over 30.

Can I use Winona's skincare with HRT, and do I need to be on HRT for it to work?

Winona’s skincare is an excellent complement to HRT but does not require HRT to work. Both can be used independently or in combination, as they serve different purposes. HRT addresses the root hormonal shifts, principally estrogen decline, that lead to a range of symptoms, including skin changes. While HRT can improve skin health, it is not a skin-specific treatment and cannot reverse existing changes like lost firmness, uneven tone, or dryness. Winona’s skincare is formulated specifically around these concerns to address skin barrier health, loss of hydration, accumulated sun damage, skin laxity, and collagen loss.

Are subscription products discounted?

Yes. Subscriptions are discounted by $10 per order. You can cancel or modify your subscription anytime.